Dr Keith Walley
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- Dr Keith
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- Walley
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Keith R. Walley, MD
Professor, University of British Columbia
Assistant Head/Basic Research, Department of Medicine, St. Paul's Hospital
Heart + Lung InstituteDr. Walley received his MD from the University of Manitoba in 1981, trained in Internal Medicine at McGill University, and subsequently trained in Critical Care Medicine at the University of Chicago. He has been a practicing Intensivist at St. Paul’s Hospital ICU and investigator at the University of British Columbia Heart + Lung Institute laboratories since 1988.
The focus of Dr. Walley's research is to investigate 1) the mechanism of decreased left ventricular contractility and other organ failure during sepsis and 2) the impact of genotype on patient outcomes in sepsis and systemic inflammatory states. He collaborates with Dr. James A. Russell on clinical trials involving critically ill patients to translate basic discoveries into clinical practice in the ICU.
Dr. Walley has published more than 150 peer-reviewed manuscripts. Some recent publications include:
Russell JA, Walley KR, Singer J, et al. Vasopressin versus norepinephrine infusion in patients with septic shock. N Engl J Med 358:877-887, 2008.
Boyd JH, Kan B, Roberts H, Wang Y, Walley KR. S100A8 and S100A9 mediate endotoxin-induced cardiomyocyte dysfunction via the receptor for advanced glycation end products. Circ Res. 102:1239-1246, 2008.
Russell JA, Walley KR, Gordon AC, Cooper DJ, Hébert PC, Singer J, Holmes CL, Mehta S, Granton JT, Storms MM, Cook DJ, Presneill JJ, Ayers D for the Vasopressin and Septic Shock Trial (VASST) Investigators. Interaction of vasopressin infusion, corticosteroid treatment and mortality of septic shock. Crit Care Med. 37(3):811-8, 2009.
Nakada TA, Russell JA, Boyd JH, Aguirre-Hernandez R, Thain KR, Thair SA, Nakada E, McConechy M, Walley KR. β2-Adrenergic receptor gene polymorphism is associated with mortality in septic shock. Am J Respir Crit Care Med. 181(2):143-149, 2010.
Thair SA, Walley KR, Nakada TA, McConechy MK, Boyd JH, Russell JA. A single nucleotide polymorphism in NF-kB inducing kinase is associated with mortality in septic shock. J Immunol. 15;186(4):2321-2328, 2011.
Nakada TA, Russell JA, Wellman H, Boyd JH, Nakada E, Thain KR, Thair SA, Hirasawa H, Oda S, Walley KR. Leucyl/cystinyl aminopeptidase gene variants in septic shock. Chest, 139;1042-1049, 2011.
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